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Assessment of Copper and Zinc Status in Hair and Urine of Young Female Descendants of NIDDM Parents

T
he concentration of copper (Cu) and Zinc (Zn) in hair and urine were studied in young non-pregnant healthy women for whom both parents were diagnosed for non-insulin-dependent diabetes mellitus (NIDDM descendants) and were compared with those of young healthy non-pregnant females with no family history of NIDDM or hypertension (non-NIDDM descendant) and NIDDM patients. The concentration of Zn in hair in NIDDM descendants was significantly higher than that of non-NIDDM descendants (p<0.001) and insignificantly higher than that of NIDDM patients. The hair Cu concentrations in NIDDM descendant and patients were significantly lower than that of non-NIDDM descendants (p<0.001). Hyperzincurea was detected in some NIDDM patients and hypocuperuria in all NIDDM descendants and patients. The data suggest that the young healthy NIDDM descendants possess high-Zn and low-Cu reserves in their bodies, and the observed perturbation appears to be associated with CU-ZN antagonism.

SK Taneja, M Mohajan, S Gupta, KP Singh. Biol Trace Elem Res 1998;62:255264.

 

 
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