Assessment of Copper and Zinc Status in Hair and Urine of Young Female Descendants of NIDDM Parents

he concentration of copper (Cu) and Zinc (Zn) in hair and urine were studied in young non-pregnant healthy women for whom both parents were diagnosed for non-insulin-dependent diabetes mellitus (NIDDM descendants) and were compared with those of young healthy non-pregnant females with no family history of NIDDM or hypertension (non-NIDDM descendant) and NIDDM patients. The concentration of Zn in hair in NIDDM descendants was significantly higher than that of non-NIDDM descendants (p<0.001) and insignificantly higher than that of NIDDM patients. The hair Cu concentrations in NIDDM descendant and patients were significantly lower than that of non-NIDDM descendants (p<0.001). Hyperzincurea was detected in some NIDDM patients and hypocuperuria in all NIDDM descendants and patients. The data suggest that the young healthy NIDDM descendants possess high-Zn and low-Cu reserves in their bodies, and the observed perturbation appears to be associated with CU-ZN antagonism.

SK Taneja, M Mohajan, S Gupta, KP Singh. Biol Trace Elem Res 1998;62:255264.